Escentric Molecules owes its existence to an aroma-molecule that does not exist in nature. Iso E Super was created in a laboratory at IFF in 1973. It remained unknown outside the world of perfumery until the launch of Escentric Molecules, though its elusive presence hovers at relatively low concentrations in the background of many fragrances for both men and women. Among perfumers, it is prized for its velvety, cocooning effect.

Molecule 01 became a cult phenomenon, hailed as the anti-fragrance fragrance and the scent of the 21st century.